Clinics (Sao Paulo). 2021;76:e2675.

Parkinson-related neuropathy

Josef Finsterer , Fúlvio Alexandre Scorza , Carla Alessandra Scorza , Ana Claudia Fiorini

DOI: 10.6061/clinics/2021/e2675

INTRODUCTION

Although Parkinson’s disease (PD) primarily affects the central nervous system, it is a multi-organ disease which also affects the eyes and the peripheral nervous system, including the autonomic fibers (,). PD-related disturbance of the peripheral nerves may result in sensory, motor, or autonomic neuropathy. Autonomic dysfunction can manifest as sicca syndrome, hypo-/hyperhidrosis, orthostatic hypotension, reduced blood pressure variability, reduced heart rate variability, nausea, constipation, vomiting, urinary dysfunction, or erectile dysfunction (). Non-motor manifestations, such as hyposmia, rapid eye movement sleep behavior disorder (RBD), constipation, or depression, may precede these motor symptoms (). Although PD-related neuropathy (PDRNP) is well recognized, relatively little data about this topic are available. Thus, this mini-review aimed to summarize and discuss previous and current data to provide an overview of the clinical presentation, diagnosis, frequency, and therapeutic management of PDRNP.

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