Search Articles
Ultrasonography Echotexture as a surrogate for Sialadenitis secondary to 131I Radioiodine Therapy for differentiated Thyroid Cancer: a review and metaanalysis
Graziele Aparecida Simões Lima , Rossana Verónica Mendoza López , Gislaine Aparecida Ozório , Ricardo Miguel Costa de Freitas , Jose Willegaignon , Marcelo Tatit Sapienza , [...]
06/Oct/2020
Ultrasonography Echotexture as a surrogate for Sialadenitis secondary to 131I Radioiodine Therapy for differentiated Thyroid Cancer: a review and metaanalysis
Graziele Aparecida Simões Lima , Rossana Verónica Mendoza López , Gislaine Aparecida Ozório , Ricardo Miguel Costa de Freitas , Jose Willegaignon , Marcelo Tatit Sapienza , [...]
DOI: 10.6061/clinics/2020/e1843
To systematically review and analyze the medical literature to assess ultrasonography echotexture changes in thyroid cancer patients for the detection of chronic sialadenitis caused by radioiodine therapy. Methods: Sources were retrieved from PubMed, Scopus, EMBASE and LILACS through November 2018. All studies that assessed ultrasonographic features before 131I administration and at 12 months after 131I administration were selected. After data extraction, statistical analysis was performed by using Stata software. Results: From a total of 435 studies, 4 studies involving 665 […]
Keywords: Differentiated Thyroid Cancer; Major Salivary Glands; Radioiodine; Sialadenitis; Ultrasonography
28/Aug/2020
Palliative radiotherapy for gastric cancer: Is there a dose relationship between bleeding response and radiotherapy?
Gustavo Arruda Viani, Caio Viani Arruda, Ana Carolina Hamamura, Alexandre Ciufi Faustino , Anielle Freitas Bendo Danelichen, Fernando Kojo Matsuura , [...]
DOI: 10.6061/clinics/2020/e1644
The aim of this study was to evaluate whether there is a relationship between bleeding response and radiotherapy dose to palliate patients with local recurrence or progression of gastric cancer (GC). To this end, we conducted a systematic review and meta-analysis of observational studies that evaluated the bleeding response in patients with GC with local recurrence or progression. A meta-regression analysis between biological effective dose (BED) and bleeding response was performed, as was subgroup analysis to evaluate the outcome by […]
Keywords: Bleeding; Gastric Cancer; Palliative; radiotherapy
14/Aug/2020
Outcomes after rotator cuff repair in the elderly as assessed by the American Shoulder and Elbow Surgeons shoulder score
DOI: 10.6061/clinics/2020/e1817
Rotator cuff tears are common among the elderly, and studies on the outcomes after rotator cuff repair in the elderly are limited. We carried out this meta-analysis with systematic literature search, aiming to clarify the outcomes after rotator cuff repair in the elderly as assessed by the American Shoulder and Elbow Surgeons (ASES) shoulder score. We conducted a literature search through October 2019 in PubMed and EMBASE databases and performed meta-analysis to calculate the summary mean difference comparing the post- […]
Keywords: ASES; Elderly; Meta-Analysis; Rotator Cuff Repair
06/Aug/2020
Diagnostic Characteristics of Serological-Based COVID-19 Testing: A Systematic Review and Meta-Analysis
Diogo Turiani Hourneaux de Moura , Thomas R. McCarty , Igor Braga Ribeiro , Mateus Pereira Funari , Pedro Victor Aniz Gomes de Oliveira , Antonio Afonso de Miranda Neto , [...]
DOI: 10.6061/clinics/2020/e2212
Serologic testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) promises to assist in assessing exposure to and confirming the diagnosis of coronavirus disease 2019 (COVID-19), and to provide a roadmap for reopening countries worldwide. Considering this, a proper understanding of serologic-based diagnostic testing characteristics is critical. The aim of this study was to perform a structured systematic review and meta-analysis to evaluate the diagnostic characteristics of serological-based COVID-19 testing. Electronic searches were performed using Medline (PubMed), EMBASE, and Cochrane […]
Keywords: Coronavirus; COVID-19; Diagnosis; SARS-CoV-2; Serological
27/Jul/2020
Laparoscopic surgery and coronavirus disease: What do we know now?
Sergio Conti Ribeiro , Ana Luisa F. Lauletta , Beatriz Couto Franco , Renata L Araujo Bezerra , Diana G B Salles Vanni , Edmund C. Baracat
DOI: 10.6061/clinics/2020/e2083
Questions regarding the transmissibility of the novel coronavirus disease (COVID-19) remain unanswered. It is known that the transmission of the severe acute respiratory syndrome coronavirus (SARS-CoV) occurs predominantly through droplets and contact. However, aerosols can be generated in some situations, such as orotracheal intubation, ventilation, and the use of electric or ultrasonic scalpels, and can therefore potentially contaminate the care team if adequate protection is not used. It is therefore necessary to assess issues of transmissibility of COVID-19 during surgery […]
Keywords: Coronavirus; COVID-19; Laparoscopy; Surgery
02/Jul/2020
Recommendations for head and neck surgical procedures during the COVID-19 pandemic
Marco A.V. Kulcsar , Fabio L.M. Montenegro , André B.O. Santos , Marcos R. Tavares , Sergio S. Arap , Luiz P. Kowalski
DOI: 10.6061/clinics/2020/e2084
The coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread exponentially worldwide. In Brazil, the number of infected people diagnosed has been increasing and, as in other countries, it has been associated with a high risk of contamination in healthcare teams. For healthcare professionals, the full use of personal protective equipment (PPE) is mandatory, such as wearing surgical or filtering facepiece class 2 (FFP2) masks, waterproof aprons, gloves, and goggles, in addition to training […]
Keywords: Complications; COVID-19; Head and Neck; Prevention; Surgery
17/Jun/2020
Lung Cancer and the COVID-19 pandemic: Recommendations from the Brazilian Thoracic Oncology Group
Clarissa Baldotto , Ana Gelatti , Arthur Accioly , Clarissa Mathias, Eldsamira Mascarenhas , Heloisa Carvalho, [...]
DOI: 10.6061/clinics/2020/e2060
New cases of the novel coronavirus disease 2019 (COVID-19), also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continue to rise worldwide following the declaration of a pandemic by the World Health Organization (WHO). The current pandemic has completely altered the workflow of health services worldwide. However, even during this critical period, patients with other diseases, like cancer, need to be properly treated. A few reports have shown that mortality due to SARS-CoV-2 is higher in elderly patients and […]
Keywords: Coronavirus; Lung Cancer; SARS-CoV
11/Jun/2020
Physiotherapy Care of Patients with Coronavirus Disease 2019 (COVID-19) - A Brazilian Experience
Renato Fraga Righetti , Mirian Akemi Onoue, Flavia Vanessa Aurea Politi, Débora Trigo Teixeira, Patricia Nery de Souza, Claudia Seiko Kondo, [...]
DOI: 10.6061/clinics/2020/e2017
Some patients with coronavirus disease (COVID-19) present with severe acute respiratory syndrome, which causes multiple organ dysfunction, besides dysfunction of the respiratory system, that requires invasive procedures. On the basis of the opinions of front-line experts and a review of the relevant literature on several topics, we proposed clinical practice recommendations on the following aspects for physiotherapists facing challenges in treating patients and containing virus spread: 1. personal protective equipment, 2. conventional chest physiotherapy, 3. exercise and early mobilization, 4. […]
Keywords: COVID-19; Mechanical Ventilation; Oxygen Therapy; Physiotherapy; Severe Acute Respiratory Syndrome Coronavirus 2
11/Jun/2020
Imaging findings in COVID-19 pneumonia
Lucas de Pádua Gomes de Farias , Eduardo Kaiser Ururahy Nunes Fonseca , Daniel Giunchetti Strabelli , Bruna Melo Coelho Loureiro , Yuri Costa Sarno Neves , Thiago Potrich Rodrigues , [...]
DOI: 10.6061/clinics/2020/e2027
The coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in Wuhan city and was declared a pandemic in March 2020. Although the virus is not restricted to the lung parenchyma, the use of chest imaging in COVID-19 can be especially useful for patients with moderate to severe symptoms or comorbidities. This article aimed to demonstrate the chest imaging findings of COVID-19 on different modalities: chest radiography, computed tomography, and ultrasonography. In addition, it intended […]
Keywords: Computed Tomography; Coronavirus; COVID-19; Radiography; SARS-CoV-2; Ultrasonography
04/Jun/2020
Adrenal Insufficiency and Glucocorticoid Use During the COVID-19 Pandemic
Madson Q. Almeida , Berenice B. Mendonca
DOI: 10.6061/clinics/2020/e2022
The coronavirus disease 2019 (COVID-19) is an emerging pandemic challenge. Acute respiratory distress syndrome (ARDS) in COVID-19 is characterized by a severe cytokine storm. Patients undergoing glucocorticoid (GC) replacement therapy for adrenal insufficiency (AI) represent a highly vulnerable group that could develop severe complications due to the SARS-CoV-2 infection. In this review, we highlight the strategies to avoid an adrenal crisis in patients with AI and COVID-19. Adrenal crisis is a medical emergency and an important cause of death. Once […]
Keywords: Adrenal Insufficiency; COVID-19; Glucocorticoid; SARS-CoV-2
25/May/2020
COVID-19 in solid organ transplantation patients: A systematic review
Lucas Souto Nacif , Leonardo Y. Zanini, Daniel R. Waisberg, Rafael S. Pinheiro, Flávio Galvão , Wellington Andraus , [...]
DOI: 10.6061/clinics/2020/e1983
Coronavirus disease (COVID-19) rapidly progresses to severe acute respiratory syndrome. This review aimed at collating available data on COVID-19 infection in solid organ transplantation (SOT) patients. We performed a systematic review of SOT patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The MEDLINE and PubMed databases were electronically searched and updated until April 20, 2020. The MeSH terms used were “COVID-19” AND “Transplant.” Thirty-nine COVID-19 cases were reported among SOT patients. The median interval for developing SARS-CoV-2 infection […]
Keywords: 2019-nCoV; COVID-19; Humans; Liver Diseases; Liver Transplantation; SARS-CoV-2; Solid Organ Transplant Recipient; Systematic Review
25/May/2020
COVID-19 and pediatric inflammatory bowel disease: How to manage it?
Roberta Paranhos Fragoso , Maraci Rodrigues
DOI: 10.6061/clinics/2020/e1962
Pediatric gastroenterologists, family members, and caregivers of patients with inflammatory bowel disease (IBD) are on alert; they are all focused on implementing prophylactic measures to prevent infection by severe acute respiratory syndrome coronavirus 2, evaluating the risks in each patient, guiding them in their treatment, and keeping IBD in remission. To face the current issues of the coronavirus disease pandemic, we have developed a synthesis of the main recommendations of the literature directed at pediatric gastroenterologists in control of patients […]
Keywords: COVID-19
18/May/2020
17β-Estradiol, a potential ally to alleviate SARS-CoV-2 infection
Ana Cristina Breithaupt-Faloppa , Cristiano de Jesus Correia , Carla Máximo Prado , Roberta Sessa Stilhano , Rodrigo Portes Ureshino , Luiz Felipe Pinho Moreira
DOI: 10.6061/clinics/2020/e1980
Considering that female sexual hormones may modulate the inflammatory response and also exhibit direct effects on the cells of the immune system, herein, we intend to discuss the sex differences and the role of estradiol in modulating the lung and systemic inflammatory response, focusing on its possible application as a treatment modality for SARS-CoV-2 patients. COVID-19 patients develop severe hypoxemia early in the course of the disease, which is silent most of the time. Small fibrinous thrombi in pulmonary arterioles […]
Keywords: 17β-Estradiol; Coagulation; COVID-19; Infection; Inflammation
11/May/2020
Susceptibility of the Elderly to SARS-CoV-2 Infection: ACE-2 Overexpression, Shedding, and Antibody-dependent Enhancement (ADE)
Jean Pierre Schatzmann Peron , Helder Nakaya
DOI: 10.6061/clinics/2020/e1912
The world is currently facing a serious SARS-CoV-2 infection pandemic. This virus is a new isolate of coronavirus, and the current infection crisis has surpassed the SARS and MERS epidemics that occurred in 2002 and 2013, respectively. SARS-CoV-2 has currently infected more than 142,000 people, causing 5,000 deaths and spreading across more than 130 countries worldwide. The spreading capacity of the virus clearly demonstrates the potential threat of respiratory viruses to human health, thereby reiterating to the governments around the […]
Keywords: ACE-2; COVID-19; Immunopathology; SARS-CoV-2
11/May/2020
Surgical Practice in the Current COVID-19 Pandemic: A Rapid Systematic Review
Flávio Carneiro Hojaij , Lucas Albuquerque Chinelatto , Gustavo Henrique Pereira Boog , Júlia Adriana Kasmirski , João Vitor Ziroldo Lopes , Fernando Mauad Sacramento
DOI: 10.6061/clinics/2020/e1923
The coronavirus disease (COVID-19) outbreak started in Wuhan, China, in December 2019, and evolved into a global problem in a short period. The pandemic has led to many social and health-care challenges. In this context, surgery is an area that is facing the need for many adaptations. In this systematic literature review, we analyzed different perspectives concerning this situation, aiming to provide recommendations that could guide surgeons and entities toward screening, elective and emergency surgeries, decision making, and operating room […]
Keywords: Coronavirus; COVID-19; Operation; Recommendations; SARS-CoV-2; Surgery